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Read Suggested Topics for Research

Browse or use the search box below to see suggestions submitted by others. Click on the text link to read the full suggestion. Suggestions are presented as they were submitted and are not edited. See Search for Guides, Reviews, and Reports for research in progress and final reports.

Suggestions that have completed the Program's selection process are identified by a topic suggestion disposition (PDF). Suggestions submitted prior to 2008 were reviewed under a different process and disposition reports may not be available.

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Apr. 11, 2013

For adult patients with Sickle cell Anemia what would the comparative effectiveness be for states to build out patient sickle cell centers of excellence, staffed by experts in the treatment of SCD vs ...

Apr. 2, 2013

Can anything be done to improve diabetic periphheral neuropathy?What is truly effective? What research seems promising? (diabetes type 2,well controlled)

Apr. 1, 2013

Whether genotyping P450 tests (CYP450 tests)are effective in 1)accurately assessing individuals' metabolic processing of various antidepressants and 2)are effective in predicting the appropriate antid ...

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Mar. 28, 2013

Who should be the one to say when a PATIENT no longer deserves REHABILITATION in PHYSICAL THERAPY, whether it is In-HOME, or OUT-PATIENT THERAPY? WHO CONTACT?

Mar. 19, 2013

1. For children with disruptive behavior disorders (DBDs), including Oppositional Defiant Disorder (ODD), Conduct disorder (CD), and Disruptive Behavior Disorder Not Otherwise Specified (DBD NOS), wha ...

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Mar. 15, 2013

What is the effectiveness of interventions intended to result in weight reduction among individuals with intellectual disabilities? Is effectiveness modified by individual characteristics, including g ...

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Mar. 14, 2013

Our topic of nomination is Postpartum Hemorrhage. The following is a list of clinical questions practitioners consider when managing such cases: • What should be considered in the initial evaluatio ...

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Mar. 14, 2013

PICO Population(s): Breastfeeding infants 6 months or less with ankyloglossia Intervention(s): Frenotomy, Frenectomy, or Frenulotomy Comparator(s): Breastfeeding management without surgical interve ...

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Mar. 11, 2013

Comparative effectiveness for the treatment of major depressive disorder (MDD) Key questions: 1. For the treatment of MDD, what is the comparative effectiveness of SSRIs, placebo, psychotherapy, exe ...

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Mar. 11, 2013

Diagnosis and management of goutKey questions: What is the accuracy of clinical criteria only in the diagnosis of acute gouty arthropathy instead of synovial fluid analysis? In adults with a history o ...

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Mar. 11, 2013

Breast cancer risk prevention in women at average risk of breast cancer: Key questions: 1. What is the impact of modifiable lifestyle factors (such as diet, weight, exercise, smoking, exogenous horm ...

Mar. 11, 2013

Effectiveness of aspirin for cancer prevention: Key questions: 1. What is the effectiveness of aspirin therapy in reducing overall cancer incidence? a. Does the effectiveness vary by cancer subty ...

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Mar. 11, 2013

Diagnosis and treatment of low back pain:Key questions:In patients with low back pain, what are the benefits and harms of identifying risk factors for chronicity and targeting treatment based on asses ...

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Mar. 7, 2013

In patients with dementia, what is the effectiveness of psychological treatment (i.e., non-pharmacological; e.g., cognitive or behavioral therapy for individuals with dementia; environmental and behav ...

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Mar. 7, 2013

What is the effectiveness of interventions intended to treat anxiety disorders in children (<18 years of age) over the long term (6-12 months)? What is the effectiveness of interventions intended ...

Mar. 7, 2013

What are the performance characteristics (e.g., sensitivity, specificity) of approaches and/or clinical features/symptoms to diagnose bipolar disorder in children? How do diagnostic methods compare in ...

Mar. 5, 2013

For patients with Injury-induced osteoarthritis, how can we stop the cycle of cartilage degradation, diapedesis, poly apoptosis and further cartilage degradation? Compare Ice/Ibuprofen from active su ...

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Mar. 2, 2013

There are many of us who have endured the results of "recalled" medical devices used for total hip replacement. What treatment exists for cobalt and chromium contaminating the human blood stre ...

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Mar. 1, 2013

Stroke and depression in comprehensive stroke centers and the development of a sdepression screen ing tool in stroke. Where can patients be referred if they have depression after stroke? Health Psycho ...

Feb. 26, 2013

1. For patients with IBS-D or -cyclic, how many/what percentage of patients have symptoms caused by non-IgE food allergies? 2. For patients with asthma or other allergy symptoms such as sinusitis or ...

Feb. 25, 2013

Research into pediatric post-traumatic stress disorder.

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Feb. 23, 2013

I have had skin problems ever since I moved here to Arizona..ulcerated sores that do not heal for months on end! The doctors here have done biopsies and found no name for this skin disease! So ...

Feb. 20, 2013

Is sporadic pneumothorax related to and or a precursor to sleep apnea?

Feb. 20, 2013

Food sensitivities are not always being recognized by health care providers

Feb. 15, 2013

Effectiveness of language interpretation (Spanish)using face to face versus language line (both by qualified/certified interpreter) in reducing patient safety medication errors in prescription complia ...

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