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Department of Health and Human Services

Read Suggested Topics for Research

Browse or use the search box below to see suggestions submitted by others. Click on the text link to read the full suggestion. Suggestions are presented as they were submitted and are not edited. See Search for Guides, Reviews, and Reports for research in progress and final reports.

Suggestions that have completed the Program's selection process are identified by a topic suggestion disposition (PDF). Suggestions submitted prior to 2008 were reviewed under a different process and disposition reports may not be available.


July 17, 2009

The key questions for this report focus on the relationship between adherence to treatment and outcomes of treatment, predictors of poor treatment response, and appropriate treatment intervals based o ...

July 14, 2009

For patients with chronic illness (diabetes, asthma, etc), what is the comparative effectiveness of interventions to address concomitant mental health issues on the outcomes of the primary chronic ill ...

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July 13, 2009

With the rates of birth by cesarean section on the rise, what factors influence (and which have the greatest impact on) the probability of delivery by cesarean in low-risk women? Which interventions a ...

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July 1, 2009

does use of generic medications for seizures result in poorer control (more ER visits and or hospitalizations than the use of brand name medications.

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July 1, 2009

Why do clinical studies for Pharmaceutical treatments differer from real life results using the same treatments? Please compare Pharmaceutical treatments outcomes in real life settings with Pharmaceut ...

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June 30, 2009

1. What is the comparative effectiveness of different hormone therapy preparations when used by postmenopausal women or women in the menopausal transition stage for reducing symptoms of menopause: hot ...

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June 30, 2009

Key Questions For patients with stable angina (stable coronary artery disease, chronic angina), 1. what is the comparative effectiveness of percutaneous coronary intervention (PCI) plus optimal me ...

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June 29, 2009

For low-risk women delivering a full-term baby vaginally, what is the comparative effectiveness of the use of nitrous oxide for pain management versus an epidural or other pain management strategies. ...

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June 22, 2009

Compared to traditional care approaches; how does doctor outreach, education, and support via internet networking technologies (such as Facebook, Twitter, and email) affect outcomes such as adherence ...

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June 17, 2009

they run too many xrays and no MRI

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June 17, 2009

For patients with PKU, there is now a pharmaceutical drug to treat this condition. In the past is was treated by medical foods that eliminated the harmful substance phenylalanine. The cost of the new ...

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View Topic Suggestion Disposition (PDF) 103 kB

June 17, 2009

POCT Testing for HbA1c

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June 17, 2009

Sepsis biomarkers and their utility

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June 17, 2009

Serum free light chain analysis for the diagnosis

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June 13, 2009

What is the comparative effectiveness of training interdisciplinary healthcare personnel in a virtual, 3D, world versus a physical simulation laboratory? Is training in a virtual, 3D, world transferr ...

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June 1, 2009

For infants with exposure to general anesthesia who may have long term adverse neurodevelopmental outcome, what is the effectiveness of an alternate anesthetic technique of regional anesthesia?

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May 29, 2009

What are the Complementary and Alternative Medicine (CAM) treaments (supplements, including herbal formulations) that are helpful in reducing PSA levels associated with begnign prostatic hyperplasia ( ...

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May 24, 2009

Migraine patients in the ER receive various IV medications from different ER doctors within the physician group. As I have watched particular drug combinations given to my patients and to my daughter ...

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May 19, 2009

For patients with allergic disease, what is the comparative effectiveness of improving health outcomes and lowering healthcare utilization by treating their disease with sublingual immunotherapy (alle ...

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May 14, 2009

For newly diagnosed patients with open-angle glaucoma, what is the comparative effectiveness of medication versus laser surgery in controlling 24-hour intraocular pressure?

May 7, 2009

For children with newly diagnosed epilepsy, ketogenic diet treatment should be evaluated against traditional anti-seizure medication.

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May 4, 2009

Why are there no discussion on comparing the effectiveness of medical foods to phamaceuticals in the treatment of diseases in children? For example the effectiveness of the Ketogenic diet in children ...

Apr. 28, 2009

Does the implementation of a free standing personal health record for children with special health care needs improve: 1) clinical outcomes, 2)care coordination, 3) communication with providers and de ...

View Topic Suggestion Disposition (PDF) 191 kB

Apr. 22, 2009

All therapy Effectiveness tests need to include compliance verification in order to ensure the validity of the test. For example a test comparing two drugs (in pill form) need to confirm that partici ...

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Apr. 22, 2009

1)DVT prophylaxis in special populations. 2)Comparative effectiveness between heparin and LWMH (low molecular weight heparins).

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