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Department of Health and Human Services

Read Suggested Topics for Research

Browse or use the search box below to see suggestions submitted by others. Click on the text link to read the full suggestion. Suggestions are presented as they were submitted and are not edited. See Search for Guides, Reviews, and Reports for research in progress and final reports.

Suggestions that have completed the Program's selection process are identified by a topic suggestion disposition (PDF). Suggestions submitted prior to 2008 were reviewed under a different process and disposition reports may not be available.


Jan. 7, 2011

For patients with cancer of the upper abdomen (eg, stomach, hepatobiliary tract, pancreas), the lower abdomen (eg, anorectal locations), or the pelvis, including but not limited to gynecologic (eg, ce ...

Dec. 30, 2010

What is the comparative effectiveness of new modalities or approaches to breast imaging, compared to standard approaches, to screen for, diagnose, plan treatment or follow up patients with breast canc ...

Dec. 30, 2010

What is the comparative effectiveness of image-guided radiotherapy (IGRT) with conventional intensity-modulated radiotherapy (IMRT) (sometimes called 4D IMRT) versus IMRT alone for improving outcomes ...

View Topic Suggestion Disposition (PDF) 136 kB

Dec. 30, 2010

What is the comparative effectiveness of various local treatments for (1) localized non-small-cell lung cancer (stage T1 or T2a) compared to stereotactic body radiotherapy in those who are not surgica ...

View Topic Suggestion Disposition (PDF) 155 kB

Dec. 23, 2010

Is transurethral radiofrequency therapy, e.g.Renessa procedure, safe and effective, especially long term, for the treatment of stress urinary incontinence?

View Topic Suggestion Disposition (PDF) 178 kB

Dec. 13, 2010

?For recipients of deceased donor kidney (SD, ECD, DCD) transplants, what is the comparative effectiveness of different induction agents (perioperative administration of an intensive immunosuppression ...

View Topic Suggestion Disposition (PDF) 162 kB

Dec. 10, 2010


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Dec. 9, 2010

Comparative effectiveness of new therapeutic approaches to the treatment of Wet AMD

View Topic Suggestion Disposition (PDF) 126 kB

Dec. 7, 2010

Is Heavy Charged Particle THerapy likely to be more cost-effective than conventional or Proton beam radiotherapy for treating cancer

View Topic Suggestion Disposition (PDF) 165 kB

Dec. 1, 2010

How can the results of Comparative Effectiveness research be turned into more valuable benefit packages?

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Dec. 1, 2010


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Nov. 30, 2010

For couples trying to get pregnant, how effective are cervical caps? Are they effective compared with intrauterine insemination? How do they compare to in vitro fertilization? Do they work better f ...

View Topic Suggestion Disposition (PDF) 124 kB

Nov. 23, 2010

• Measurement and outcomes need consensus definitions • State Medicaid programs need robust HEDIS and NCQA measures for all severe and persistent mental health conditions. • Consensus definitions wo ...

View Project Status

View Topic Suggestion Disposition (PDF) 52 kB

Nov. 23, 2010

Infrastructure for research • Infrastructure is needed that supports longitudinal studies including developing new investigators/investigator teams and providing additional training • Facilitate ...

Nov. 23, 2010

• Identify disparities and reasons for disparities and reevaluate the framework for researching disparities The following article was used in answering this question: Davis, L. M., Kilburn, M. R., an ...

Nov. 23, 2010

• Role of the therapeutic relationship (and different methods for evaluating that role) in the service of improved outcomes • For individuals with serious mental illness, what facets of the therapeut ...

Nov. 23, 2010

• Treatment approaches to avoid early mortality and morbidity, which may be due to psychiatric manifestations, including suicide, as well as the result of earlier onset or greater likelihood of genera ...

View Topic Suggestion Disposition (PDF) 138 kB

Nov. 23, 2010

• The roles of the psychiatric hospital, lengths of stay, and transition support services after discharge

View Topic Suggestion Disposition (PDF) 1.2 MB

Nov. 23, 2010

• Compare the effectiveness of strategies to increase adherence to evidence-based guidelines and treatment regimens. One nominator recommended rewording this item as below, stating that it would be m ...

View Topic Suggestion Disposition (PDF) 60 kB

Nov. 23, 2010

• Comparative effectiveness of correctional programs, facilities, and interventions for people involved with the criminal justice system with serious mental illness. • Please see the attached presen ...

Nov. 23, 2010

• Prevention, early identification, trajectories, and developmental perspectives of serious mental illness • Please see “Catch Them Before They Fall: How to Implement Mental Health Screening Program ...

Nov. 23, 2010

• Dissemination and implementation • e.g., of health system strategies

Nov. 23, 2010

• Compare the effectiveness of strategies to reduce stigma, prejudice, and discrimination among individuals with serious mental illness.

View Topic Suggestion Disposition (PDF) 1.3 MB

Nov. 22, 2010

Is the Wireless Motility Capsule (WMC) (i.e. SmartPill) safe and effective in the diagnosis and management of gastrointestinal motility disorders including gastroparesis and refractory constipation? C ...

View Topic Suggestion Disposition (PDF) 129 kB

Nov. 9, 2010

PTNS vs SNS for overactive bladder

View Topic Suggestion Disposition (PDF) 192 kB

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