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Department of Health and Human Services

Read Suggested Topics for Research

Browse or use the search box below to see suggestions submitted by others. Click on the text link to read the full suggestion. Suggestions are presented as they were submitted and are not edited. See Search for Guides, Reviews, and Reports for research in progress and final reports.

Suggestions that have completed the Program's selection process are identified by a topic suggestion disposition (PDF). Suggestions submitted prior to 2008 were reviewed under a different process and disposition reports may not be available.


June 1, 2011

What is the comparative effectiveness of using versus not using clinical decision support tools to select immediate treatment versus observation and improve net health outcomes for patients with prema ...

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June 1, 2011

What is the comparative effectiveness of different models of survivorship care and sets of services on late and long-term net health outcomes (e.g., for breast cancer)?

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June 1, 2011

For cancer patients, what is the comparative effectiveness of different strategies to manage the symptoms of chemotherapy for improving net health outcome?

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June 1, 2011

For patients with rectal cancer, what is the comparative effectiveness of neoadjuvant (preoperative) radiation therapy plus surgery versus surgery alone to reduce risk of local recurrence and improve ...

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June 1, 2011

For patients with rectal cancer, what is the comparative effectiveness of different imaging modalities, alone or in combination (i.e., incremental benefit from using more than one modality) for preope ...

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May 28, 2011

The first wave of children with autism since rates started to skyrocket are beginning to exit the school system yet no one has studied what we can learn from this group (many of whom did not have inte ...

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May 10, 2011

For children and young adults with T-cell immunophenotype acute lymphoblastic leukemia (ALL) does the administration of prophylactic cranial irradiation improve event-free and over-all survival.

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May 3, 2011

Benefits and harms associated with cardiopulmonary resuscitation in patients with advanced cancers

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Apr. 22, 2011

1. What is the etiology of acute and chronic urinary retention in adults? 2. How do we define urinary retention (base case) including those with known neurologic problems? (aka What is considered a ...

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Apr. 19, 2011

for people with post surgical (total thyroidectomy) hypothyroidism what is the comparative effectiveness of medications used for TSH (T4) control when there are problems keeping the TSH level within r ...

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Apr. 12, 2011

Trigeminal Neuralgia is a devastating problem that often ends in suicide. The best treatment at this time is the drug Felbamate which can cause Kidney failure in as little as two weeks in most patient ...

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Apr. 5, 2011

• Does the availability of telemedicine services improve access to subspecialty care and address disparities in care for children who live in rural or underserved areas? • How can telemedicine servic ...

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Apr. 4, 2011

For pediatric patients with community acquired pneumonia admitted to the hospital what is the best antibiotic regiment?

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Mar. 31, 2011

Effectiveness of pain management in arachnoiditis. TENS, Ultram, Neurontin, etc

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Mar. 31, 2011

For pregnant woman and women with infants, how accurate is information on the subject of (benefits, ease of initiating, continuing) breastfeeding ? information than others?

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Mar. 31, 2011

What are the comparative side effects of antidepressant medication side effects on low socio-economic ethnic/racial minority adolescents versus white low socio-economic adolescents?

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Mar. 26, 2011

teen pregnancy

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Mar. 2, 2011

For children ages 10-17, what is being done nationally to develop a diabetes prevention program (DPP) curriculum?

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Feb. 18, 2011

Cost effective long term care of the frail elderly

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Feb. 15, 2011

In patients with ostoarthrisis, what is the effectiveness of alkaline ionized water from a Chanson Water ionizer in improving health outcomes and pain and stiffness relief vs. current drug treatments. ...

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Feb. 12, 2011

To test whether CKD patients who are referred to renal nutritionists and receive counseling on how to change their diet to conform to their kidney condition are less likely to require dialysis and/or ...

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Feb. 10, 2011

Key Questions 1. Does routine preoperative testing compared to no testing or alternative testing strategies improve outcomes (such as surgical complications, other morbidity, and mortality) among pat ...

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Jan. 30, 2011

For adult patients with bipolar disorder, what courses of treatment are available? Concurrently, which treatments provide statistically better treatment results?

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Jan. 20, 2011

Peripheral Artery Disease (PAD) - defined as peripheral artery disease of the lower extremities 1) Does aspirin reduce the risk of adverse cardiovascular events (MI, stroke, cardiovascul ...

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Jan. 20, 2011

Unstable Angina (UA)/Non–ST-Elevation Myocardial Infarction (NSTEMI) 1) Is there an overall positive benefit to risk ratio for triple antithrombotic therapy (aspirin, clopidogrel, warfarin) in post ...

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