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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

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Clinical Questions Addressed by the Comparative Effectiveness Review (1 of 2)

The comparative effectiveness review focused on the first-generation (FGAs) and second-generation (SGAs) used to treat adults (ages 18 to 64 years) with schizophrenia, schizophrenia-related psychoses, and bipolar disorder (all are approved indications). Clinical questions addressed by the comparative effectiveness review include:

  • What are the comparative efficacy and effectiveness of FGAs versus SGAs for improving core illness symptoms?
  • What is the comparative effectiveness of FGAs versus SGAs for improving functional outcomes and decreasing utilization of the health care system?