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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

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Introduction to First-Generation and Second-Generation Antipsychotics (3 of 4)

Individuals taking antipsychotics of either class (first generation and second generation) may discontinue use because of adverse effects, lack of improvement in symptoms, or both.

A synthesis of the evidence from the clinical literature that directly compares the first-generation and second-generation antipsychotics may inform treatment choices that balance benefits and adverse effects for adults with psychosis, mania, or bipolar disorder.