First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Outline of Material
The presentation begins with an introduction to antipsychotics classified as first-generation and second-generation. The systematic review methods used in the comparative effectiveness review are presented. The clinical questions addressed by the comparative effective review are presented, followed by the results of studies and evidence-based conclusions about the comparative effectiveness and adverse effects of antipsychotics. Gaps in knowledge are presented, and the presentation concludes with suggestions about what to discuss with patients and their caregivers.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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