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Drug Therapy for Rheumatoid Arthritis in Adults
Authors: John I. Gomez, MD
Analytic Methods Used in the Systematic Review
To compare study results systematically, the authors identified these minimally clinically important differences:
- American College of Rheumatology 20-percent improvement criteria (ACR20): Finding a statistically significant difference in the proportion of patients achieving ACR20 between treatment and control groups
- A disease activity score (DAS) of <1.6
- A DAS28 of <2.6
- Functional ability: Difference between treatment and control groups in Health Assessment Questionnaire score is ≥0.22
- Health-related quality of life: The difference in the SF-36 (Medical Outcomes Study Short Form) is 2.6–4.4 for physical component score
- A change in joint damage of 5.0 according to the Sharp/van de Heijde method
Keywords: rheumatoid arthritis | RA | DMARDs | disease-modifying | antirheumatic | anti-rheumatic | rheumatic | biologic | oral | ACR20 | disease activity | functional ability | HAQ | Health Assessment Questionnaire | health-related quality of life | SF-36 | Sharp/van de Heijde | joint damage
- Donahue KE, Jonas D, Hansen RA, et al. Drug Therapy for Rheumatoid Arthritis in Adults: An Update. Comparative Effectiveness Review No. 55 (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I). Rockville, MD: Agency for Healthcare Research and Quality; April 2012. AHRQ Publication No. 12-EHC025-EF. Available at www.effectivehealthcare.ahrq.gov/dmardsra.cfm.
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