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Insulin Delivery and Glucose Monitoring Methods for Diabetes Mellitus: Comparative Effectiveness

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Background: Uncertainties Associated With Insulin Delivery and Glucose Monitoring Methods in Managing Diabetes Mellitus

Given new technologies in insulin delivery and glucose monitoring, clinicians are now faced with determining which patient populations benefit most from the available modes of intensive insulin therapy (MDI vs. CSII) and strategies for glucose monitoring (SMBG vs. rt-CGM) in terms of improved glycemic, clinical, and patient-reported outcomes. Therefore, the relative benefits and/or harms of modes of intensive insulin therapy (MDI vs. CSII) and strategies for glucose monitoring (SMBG vs. rt-CGM) require systematic evaluation.

Abbreviations: CSII = continuous subcutaneous insulin infusion; MDI = multiple daily injections; rt-CGM = real-time continuous glucose monitoring; SMBG = self-monitoring of blood glucose