Disease-Modifying Antirheumatic Drugs in Children With Juvenile Idiopathic Arthritis
Summary of Study Characteristics Evaluated in the Effectiveness Review: PICOTS
Development of clinical studies of effectiveness of medical interventions is guided by the PICOTS (population, interventions, comparators, outcomes, timing, and setting) framework. These items are critical elements that will help to answer important clinical questions. In the CER, the clinical study literature was reviewed and summarized by using the PICOTS framework. The evidence concerning the outcomes identified here was examined in detail, and strength-of-evidence determinations were made only for these key outcomes.
Population: Individuals 18 years or younger, with a diagnosis of juvenile idiopathic (JIA), rheumatoid (JRA), or chronic (JCA) arthritis
- JIA = International League of Associations for Rheumatology (ILAR)
- JRA = American College of Rheumatology (ACR)
- JCA = European League Against Rheumatism (EULAR)
Interventions: Biologic and nonbiologic DMARDs
Comparators: Conventional treatment, meaning NSAIDs and intra-articular corticosteroids, with or without methotrexate or another DMARD
Outcomes: Intermediate and long-term disease status, health status, inflammation markers, and radiographic progression
Timing: Intervention period of at least 3 months
Setting: Any setting for treatment of JIA
Keywords: juvenile idiopathic arthritis | JIA | JRA | juvenile rheumatic arthritis | JCA | juvenile chronic arthritis | DMARDs | disease-modifying | antirheumatic | anti-rheumatic | rheumatic | biologic | nonbiologic | non-biologic | NSAIDs | intra-articular corticosteroids | DMARDs | disease status | health status | inflammation | radiographic progression | PICOTs
- Kemper A, Coeytaux R, Sanders G, et al. Disease-Modifying Antirheumatic Drugs (DMARDs) in Children With Juvenile Idiopathic Arthritis (JIA). Comparative Effectiveness Review No. 28 (Prepared by the Duke Evidence-based Practice Center under Contract No. HHSA 290-2007-10066-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC039-EF. Available at www.effectivehealthcare.ahrq.gov/dmardsjia.cfm.
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