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Off-Label Use of Atypical Antipsychotics: An Update

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Adverse Effects of Interest in the Comparative Effectiveness Review

The adverse effect profiles of the atypical antipsychotics are not expected to vary according to indication. An exception is dementia, which is associated with older age. Patient age is expected to influence the adverse effect profiles. Reported adverse events were evaluated according to age groups: (1) adults 18–64 years of age and (2) elderly adults aged 64 and older. The key adverse events of interest were mortality, weight gain, endocrine disorders and diabetes, cardiovascular events, extrapyramidal symptoms, and sedative effects.