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Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations
Report Findings: Prevalence of Positive Serological Test Results Among Healthy Children
The prevalence of positive tests results in healthy children was as follows:
- Antinuclear antibody: 0–18 percent (median = 3%)
- Rheumatoid factor: approximately 3 percent (median = 0%)
- Cyclic-citrullinated peptide antibody: 0–0.6 percent (median <1%)
- Wong KO, Bond K, Homik J, et al. Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests for Evaluating Musculoskeletal Complaints in Children. Comparative Effectiveness Review No. 50 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. HHSA 290-2007-10021-I). Rockville, MD: Agency for Healthcare Research and Quality; March 2012. AHRQ Publication No. 12-EHC015-EF. Available at www.effectivehealthcare.ahrq.gov/anatest.cfm.
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