Skip Navigation
Department of Health and Human Services www.hhs.gov
 
Slide Tray
0 slides

Return to Slide Library

Slides

Add Presentation to Slide Tray Presentation:

Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations

Slide: 13 of 23

Clinical Questions Addressed by the CER (2 of 3)

In preparing the report on which this continuing medical education activity is based, the authors aimed to answer five Key Questions (KQs). KQ 3 is listed below:

KQ 3. Diagnostic performance

KQ 3.1. In children and adolescents aged 18 years or younger with undiagnosed musculoskeletal (MSK) pain, what is the test performance (sensitivity, specificity, and positive and negative predictive values) of ANA for pSLE when compared with a clinical diagnosis?

KQ 3.2. In children and adolescents aged 18 years or younger with undiagnosed MSK pain, what is the test performance (sensitivity, specificity, and positive and negative predictive values) of ANA for JIA when compared with a clinical diagnosis?

KQ 3.3. In children and adolescents aged 18 years or younger with undiagnosed MSK pain, what is the test performance (sensitivity, specificity, and positive and negative predictive values) of RF for pSLE when compared with a clinical diagnosis

KQ 3.4. In children and adolescents aged 18 years or younger with undiagnosed MSK pain, what is the test performance (sensitivity, specificity, and positive and negative predictive values) of RF for JIA when compared with a clinical diagnosis

KQ 3.5. In children and adolescents aged 18 years or younger with undiagnosed MSK pain, what is the test performance (sensitivity, specificity, and positive and negative predictive values) of CCP for pSLE when compared with a clinical diagnosis?

KQ 3.6. In children and adolescents aged 18 years or younger with undiagnosed MSK pain, what is the test performance (sensitivity, specificity, and positive and negative predictive values) of CCP for JIA when compared with a clinical diagnosis?

Abbreviations:

ANA = antinuclear antibody
CCP = cyclic-citrullinated peptide
JIA = juvenile idiopathic arthritis
pSLE = pediatric systemic lupus erythematosus
RF = rheumatoid factor