Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update
Background: Treatment of GERD (1 of 2)
For individuals with chronic GERD, most authorities consider the goals of therapy to be an improvement in symptoms and quality of life, healing of erosive esophagitis, and prevention of recurrent esophagitis and complications (such as Barrett’s esophagus and esophageal stricture). However, there remains considerable uncertainty about how these objectives should be achieved. The medical treatment of GERD is based on pharmacological suppression of gastric acid. Depending on the severity of symptoms and the clinical response, intermittent (on-demand), periodic, or continuous use of prescription or over-the-counter medications, especially histamine type 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), may be used.
GERD = gastroesophageal reflux disease
Keywords: complications | H2RA | histamine type 2 receptor antagonist | PPI | proton pump inhibitor | treatment
- Ip S, Chung M, Moorthy D, et al. Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update. Comparative Effectiveness Review No. 29 (Prepared by the Tufts Evidence-based Practice Center under Contract No. HHSA 290-2007-10055-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC049-EF. Available at www.effectivehealthcare.ahrq.gov/gerdupdate.cfm.
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