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Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update

Slide: 4 of 26

Background: Pathophysiology of GERD

Chronic GERD is a common health condition resulting from frequent exposure of the esophagus to gastric contents, such as acid and pepsin, that may be harmful to esophageal epithelium. The physical barrier to reflux is the lower esophageal sphincter, which is anchored by the crural diaphragm. The antireflux barrier may be disrupted by a hiatal hernia or a hypotensive lower esophageal sphincter, alone or in combination.

GERD = gastroesophageal reflux