Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update
Clinical Questions Addressed by the CER (3 of 5)
KQ 3 asked: Regarding treatment adherence* and persistence†:
a. What are the adherence and persistence to medications for the treatment and prevention of osteoporosis?
b. What factors affect adherence and persistence?
c. What are the effects of adherence and persistence on the risk of fractures?
*Adherence = Compliance, which is “the extent to which a patient acts in accordance with the prescribed interval and dose of a dosing regimen” (Cramer et al., 2008).
†Persistence = “The duration of time from initiation to discontinuation of therapy” (Cramer et al., 2008).
Keywords: adherence | bone density | fracture | low bone density | osteopenia | osteoporosis | prevention | skeletal | Bone
- Cramer JA, Roy A, Burrell A, et al. Medication compliance and persistence: terminology and definitions. Value Health 2008;11(1):44-7. PMID: 18237359.
- Newberry SJ, Crandall CC, Gellad WG, et al. Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update to the 2007 Report. Comparative Effectiveness Review No. 53 (Prepared by the Southern California Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; February 2012. AHRQ Publication No. 12-EHC023-EF. Available at www.effectivehealthcare.ahrq.gov/reports/lbd.cfm.
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