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Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update

Slide: 13 of 40

Clinical Questions Addressed by the CER (3 of 5)

KQ 3 asked: Regarding treatment adherence* and persistence†:

a. What are the adherence and persistence to medications for the treatment and prevention of osteoporosis?
b. What factors affect adherence and persistence?
c. What are the effects of adherence and persistence on the risk of fractures?

*Adherence = Compliance, which is “the extent to which a patient acts in accordance with the prescribed interval and dose of a dosing regimen” (Cramer et al., 2008).

†Persistence = “The duration of time from initiation to discontinuation of therapy” (Cramer et al., 2008).