Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Background: Vagus Nerve Stimulation (VNS)
VNS involves surgically placed electrodes around the left vagus nerve to modulate mood and control seizures. A current of >1 milliamperes and a frequency of 1–145 Hertz is applied for 30 seconds every 5 minutes, generally for 10 weeks. VNS is approved by the FDA for treating TRD; however, availability of this treatment option is limited because its use in the United States is still largely investigational.
Keywords: FDA approval | duration | placement site | availability | vagus nerve stimulation | VNS | usual dosage
- Gaynes BN, Lux L, Lloyd S, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33 (Prepared by RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC056-EF. Available at: http://www.effectivehealthcare.ahrq.gov/trd.cfm.
- Daban C, Martinez-Aran A, Cruz N, et al. Safety and efficacy of vagus nerve stimulation in treatment-resistant depression. A systematic review. J Affect Disord 2008 Sep;110(1-2):1-15. PMID: 18374988.
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