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Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults

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Comparative Effectiveness Review Study Criteria

The most applicable studies were those that evaluated patients with an episode of MDD who had not recovered after two or more adequate antidepressant medication treatments, regardless of the class of antidepressant used or whether the treatment failures were required to be in the current episode. Of note, evaluated studies were not necessarily designed with the above specifications in mind. In addition, many studies included mixed populations of patients with MDD and bipolar disorder. Included studies used a cutoff of less than or equal to 20% bipolar patients in the population. Evaluated studies included both randomized controlled trials and observational studies. Specific inclusion and exclusion criteria differed by KQ. A complete list of these criteria is available in the full report.