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Analgesics for Osteoarthritis—An Update

Slide: 24 of 32

Effects of Adding an H-2 Antagonist, Misoprostol, or a PPI on GI Adverse Effects Associated With NSAIDs (3 of 3)

Celecoxib plus a PPI may reduce the risk of endoscopic ulcers and ulcer complications when compared to celecoxib alone in individuals at average risk.
Strength of evidence: Moderate

When compared with placebo, double-dose H-2 antagonists could be more effective than standard-dose antagonists for reducing endoscopically detected gastric and duodenal ulcers.
Strength of evidence: High