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Analgesics for Osteoarthritis—An Update

Slide: 23 of 32

Effects of Adding an H-2 Antagonist, Misoprostol, or a PPI on GI Adverse Effects Associated With NSAIDs (2 of 3)

In individuals with increased risk of GI bleeding who were prescribed a nonselective NSAID, adding a PPI resulted in a reduced risk of endoscopically detected duodenal ulcers when compared with misoprostol or H-2 antagonists, a lower risk of endoscopically detected gastric ulcers when compared with H-2 antagonists, and a similar risk of endoscopically detected gastric ulcers when compared with misoprostol.
Strength of evidence: High