Analgesics for Osteoarthritis—An Update
Factors Affecting Outcomes: Pre-existing Disease
The risk of GI bleeding was higher in individuals taking NSAIDs who had had previous bleeding than those who had not. Two trials found high rates of recurrent ulcer bleeding in patients randomized to either celecoxib (4.9% to 8.9% with 200 mg twice daily) or a nonselective NSAID and a proton pump inhibitor (PPI; 6.3%).
Strength of evidence: Moderate
- Chou R, McDonagh M, Nakamoto E, et al. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis: An Update of the 2006 Report. Comparative Effectiveness Review No. 38 (Prepared by Oregon Evidence-based Practice Center under Contract No. HHSA 290-2007-10057-I). Rockville, MD: Agency for Healthcare Research and Quality; October 2011. AHRQ Publication No. 11(12)-EHC076-EF. Available at: http://www.effectivehealthcare.ahrq.gov/reports/analgesicsupdate.cfm.
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