Analgesics for Osteoarthritis—An Update
Comparative Adverse Effects of Oral Agents: GI effects (2 of 2)
The partially selective NSAIDs meloxicam (RR 0.53, 95% CI 0.29 to 0.97) and etodolac (RR 0.32, 95% CI 0.15 to 0.71) were associated with a lower risk of ulcer complications or symptomatic ulcers when compared with nonselective NSAIDs in a systematic review of randomized trials.
Strength of evidence: Moderate
In seven large observational studies, naproxen was associated with a higher risk of serious GI adverse effects than was ibuprofen.
Strength of evidence: High
- Chou R, McDonagh M, Nakamoto E, et al. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis: An Update of the 2006 Report. Comparative Effectiveness Review No. 38 (Prepared by Oregon Evidence-based Practice Center under Contract No. HHSA 290-2007-10057-I). Rockville, MD: Agency for Healthcare Research and Quality; October 2011. AHRQ Publication No. 11(12)-EHC076-EF. Available at: http://www.effectivehealthcare.ahrq.gov/reports/analgesicsupdate.cfm.
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