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Analgesics for Osteoarthritis—An Update

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Analgesics for Osteoarthritis—An Update

This slide set is based on a comparative effectiveness review (CER) titled Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review, which was developed by the Oregon Evidence-based Practice Center, Oregon Health & Science University, Portland, OR, for the Agency for Healthcare Research and Quality (AHRQ) under Contract No. 290-2007-10057-I and is available online at

CERs are comprehensive systematic reviews of the literature that usually compare two or more types of treatment with usual care for the same disease. This CER is an update to the 2006 report Comparative Effectiveness and Safety of Analgesics for Osteoarthritis that assessed the comparative efficacy and safety of nonopioid oral medications (selective and nonselective nonaspirin nonsteroidal anti-inflammatory drugs [NSAIDs], aspirin, salsalate, and acetaminophen), over-the-counter supplements (chondroitin and glucosamine), and topical agents (NSAIDs and rubefacients, including capsaicin) for osteoarthritis. The literature included in this review was identified in searches for trials and studies by combining terms for drug names with terms for relevant research designs. Only studies on adults were included. Searches were conducted for studies published through January 2011. It should be noted that this report does not discuss opioid medications.