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Clostridium difficile Infections: Diagnosis, Treatment, and Prevention

Slide: 12 of 33

Introduction: Incidence of C.difficile Infection (CDI)

Clostridium difficile infection (CDI) is a serious healthcare-associated infection and a growing health care problem. CDI incidence is estimated at 6.5 cases per 10,000 patient days in hospital. About 250,000 hospitalizations were associated with CDI in 2005. Direct attributable mortality from CDI has been reported to be as high as 6.9 percent of cases. Elderly people in hospitals account for the vast majority of severe morbidity and mortality. Residents of long-term care facilities are also at higher risk. Incidence rates may increase by four-fold or five-fold during outbreaks. The increase in incidence and severity of C. difficile infection may be attributed to the emergence of a hypervirulent C. difficile strain, known as the North American Pulsed Field type 1 (NAP1) strain.