Comparing Medications for Adults With Type 2 Diabetes
Gaps in Knowledge
This updated systematic review synthesized the current literature about the comparative effectiveness and safety of diabetes medications when used as monotherapy and in two-drug combinations. A few deficiencies were identified in the published literature that need to be addressed by future research to meet the decisionmaking needs of patients, providers, and policymakers. Studies are needed to address the efficacy of treatments for patients with type 2 diabetes who have varying levels of underlying cardiovascular and renal disease, for people of different ethnic groups, or people with variant forms of type 2 diabetes. Additional comparative studies are needed that address comparisons of newer medications, combinations with basal or premixed insulin and MET or other antidiabetic agents, and additional two-drug combinations. Sufficient data on event rates are needed to analyze major clinically important outcomes, adverse events, and long-term complications of type 2 diabetes.
Keywords: gaps in knowledge | future research | patient subpopulations | subgroup analysis | insulin
- Bennett WL, Wilson LM, Bolen S, et al. Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update. Comparative Effectiveness Review No. 27. (Prepared by Johns Hopkins University Evidence-based Practice Center under Contract No. 290-02-0018.) AHRQ Publication No. 11-EHC038-EF. Rockville, MD: Agency for Healthcare Research and Quality. March 2011. Available at: http://effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productID=644.
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