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Comparing Medications for Adults With Type 2 Diabetes

Slide: 11 of 35

Priority Medication Comparisons

Prior to beginning this update, an extensive preliminary literature review was conducted and evidence gaps identified in the 2007 review were assessed. Head-to-head comparisons of medications that should be of greatest relevance to clinicians and their patients were the focus of the updated review. The scope was broadened by including two newer medication classes, namely the glucagon-like peptide-1 (GLP-1) receptor agonists and the dipeptidyl peptidase-4 (DPP-4) inhibitors and two-drug combinations of medications. There were 166 articles identified, which included 75 trials and 19 observational studies that have been published since the completion of the 2007 review. Included in the updated review were 19 articles with newer medication class comparisons, 77 articles that contained either metformin or a thiazolidinedione in combination with another medication, and 8 articles with comparisons that included insulin preparations in combination with other medications. The comprehensive review of the newer medication classes in comparison to other medications and comparisons of combination therapies is an important contribution to the literature because it is the first to address this many comparisons for a wide range of outcomes in patients with type 2 diabetes mellitus.