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Comparative Effectiveness of Therapies for Children With Autism Spectrum Disorders

Slide: 34 of 36

Gaps in Knowledge

There are no or few studies that describe the following:

  • Direct comparisons of the effects of different treatment approaches (e.g., no direct comparison of UCLA/Lovaas and the Early Start Denver Model), and there are few data on practical effectiveness or feasibility beyond research studies.
  • Which children are likely to benefit from particular interventions.
  • Generalization of treatment effects to contexts outside of the treatment context (e.g., settings), components of multicomponent therapies that drive effectiveness, and predictors of treatment success.
  • Which specific treatment approaches to use in children under 2 years of age who are at high risk of developing an ASD based upon behavioral, medical, or genetic risk factors.
  • Whether there are any harms associated with behavioral, educational, allied health, or CAM interventions.