Comparative Effectiveness of Therapies for Children With Autism Spectrum Disorders
Key Question 2: Modifiers of Treatment Outcomes
Few studies were designed or powered to identify modifiers of treatment effect. True treatment modifiers were only demonstrated in one included study. Many other studies failed to find a relationship between autism symptoms and treatment response. The evidence report identified several potential correlates that warrant future study, including: pretreatment IQ and language skills; age at initiation of treatment; social skills, imitation skills, and aloofness (UCLA/Lovaas); and diagnosis.
- Warren Z, Veenstra V-W, Stone W, et al. Therapies for Children With Autism Spectrum Disorders. Comparative Effectiveness Review No. 26 (Prepared by the Vanderbilt University Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; April 2011. AHRQ Publication No. 11-EHC029-EF.
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