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Traumatic Brain Injury and Depression

Slide: 19 of 25

Key Questions 4 and 5 — Outcomes and Comparisons of Treatments for Depression After Traumatic Brain Injury

To understand the treatment options for patients with TBI and subsequent depression, the authors of this report sought publications that clearly documented the intervention, duration, and response to treatment. Using this approach, only two publications were identified that specifically addressed outcomes among individuals who were diagnosed with depression, had a history of TBI, and were treated with a selective serotonin reuptake inhibitor. The first was a U.S. randomized, placebo-controlled clinical trial; the second was a Canadian open-label case series. There were no head-to-head studies of treatments for depression after TBI on which to base conclusions about effectiveness.