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Traumatic Brain Injury and Depression

Slide: 16 of 25

Key Question 1 — Prevalence and Incidence of Depression in Traumatic Brain Injury

Across all included populations, measures, and time frames, the aggregate prevalence of depression after TBI was 31.0% (range: 12.2–76.7%). This figure is derived from 112 publications based on 79 distinct study populations. Data are sparse to assess whether severity of injury influences risk of depression. Too few studies isolate a sufficient number of patients with mild TBI to compare to those with moderate and/or severe injuries to make valid severity-based estimates of prevalence. Likewise, stratification of prevalence by explanatory factors such as age, gender, area of brain injured, or mechanism of injury is not possible within the current body of literature.