Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Evidence on the Comparative Effectiveness Regarding Quality of Life and Adverse Events: 3DCRT vs. 2DRT
Four studies reported on late xerostomia with a range of differences between 3DCRT and 2DRT of 15 to 48 percentage points, except one study that favored 2DRT by 10 percentage points. Only one result was statistically significant.
• One study compared quality-of-life outcomes between 3DCRT and 2DRT but did not report a statistical comparison.
• Acute xerostomia, acute mucositis, late mucositis, acute dysphagia, acute skin toxicity, late skin toxicity, and late osteoradionecrosis, and bone toxicity were reported in a few studies; differences between 3DCRT and 2DRT were small and not statistically significant, not exceeding a difference of 9 percentage points.
• The available literature is of insufficient quantity and quality to ascertain whether there are differences in quality of life or adverse events, including late xerostomia, between 3DCRT and 2DRT.
Keywords: 2DRT | 3DCRT | adverse events | head and neck cancer | outcomes | quality of life | radiotherapy | comparative effectiveness
- Samson DJ, Ratko TA, Rothenberg BM, et al. Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer, Comparative Effectiveness Review No. 20 (Prepared by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. 290-02-0026). Rockville, MD: Agency for Healthcare Research and Quality; May 2010. AHRQ Publication No. 10-EHC014-EF.
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