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Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer

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Planned Comparisons

The CER on which this CME activity is based considered the comparative effectiveness and safety of four types of external-beam radiotherapy: three-dimensional conformal radiotherapy (3DCRT), two-dimensional radiotherapy (2DRT), intensity-modulated radiotherapy (IMRT), and proton beam therapy. Of 2,679 records found through an electronic literature search, 354 articles were retrieved for further screening. Thirty-eight articles that described comparative studies were abstracted. Of the 38 comparative studies, 5 were three-arm designs, so there were 48 total comparisons. Interventions in comparative studies included IMRT, 3DCRT and 2DRT; none included proton beam therapy.