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Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care

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The CER Development Process (2)

Utilization data for rFVIIa was taken from the Perspective Comparative Database of Premier, Inc., in Charlotte, NC (2000–2008). A comprehensive systematic review of the literature was conducted from 10 electronic databases, grey literature, trial registries, and reference lists. Studies on the spectrum of rFVIIa off-label use, effectiveness of rFVIIa for the five AHRQ-selected indications, and studies on the potential harms for the five indications were included. All methods used in the review followed version 1.0 of the Methods Reference Guide for Effectiveness and Comparative Effectiveness Reviews published by AHRQ (draft available at: The draft CER was prepared and published online and was subject to public comment and peer review. Once finalized, the complete report was published on the Effective Health Care Program Web site (available at: