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Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and/or Angiotensin II Receptor Blockers Added to Standard Medical Therapy for Treating Patients With Stable Ischemic Heart Disease and Preserved Left Ventricular Systolic Function

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Characteristics of Stable Ischemic Heart Disease

People with stable ischemic heart disease can have advanced atherosclerosis, which reduces the maximal ability of the coronary arteries to supply blood to the myocardium (Gibbons et al., 2002). Symptoms of stable ischemic heart disease range from asymptomatic ischemic episodes to severely debilitating symptoms and from large vessel disease to diffuse microvascular disease (Gibbons et al., 2002). People with stable ischemic heart disease may or may not have had an acute coronary syndrome in the past but are at increased risk of such an event in the future (Gibbons et al., 2002).