First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Introduction to First-Generation and Second-Generation Antipsychotics (3 of 4)
Individuals taking antipsychotics of either class (first generation and second generation) may discontinue use because of adverse effects, lack of improvement in symptoms, or both.
A synthesis of the evidence from the clinical literature that directly compares the first-generation and second-generation antipsychotics may inform treatment choices that balance benefits and adverse effects for adults with psychosis, mania, or bipolar disorder.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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