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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

Slide: 4 of 35

Introduction to First-Generation and Second-Generation Antipsychotics (2 of 4)

First-generation antipsychotics (FGAs) are associated with side effects that are difficult to manage and, in some cases, are irreversible. Examples of the more difficult side effects are extrapyramidal symptoms and tardive dyskinesia. Second-generation antipsychotics (SGAs) were developed in response to a desire to avoid these adverse effects. SGAs are not as strongly associated with neuromotor side effects as the FGAs. However, they are associated with elevated risks for dyslipidemia, weight gain, metabolic syndrome, and diabetes mellitus.