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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

Slide: 34 of 35

Conclusions (3 of 3)

  • There is little evidence from head-to-head comparisons of first-generation antipsychotics and second-generation antipsychotics to estimate differences in risk for the most clinically important adverse effects: mortality, diabetes mellitus, tardive dyskinesia, and metabolic syndrome.
  • Clinical studies are still lacking to describe comparative long-term efficacy and safety, optimal dosage and duration of treatment, and risks and benefits in patient subpopulations.