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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

Slide: 32 of 35

Conclusions (1 of 3)

  • Few clinically important differences are found between first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) in core illness symptoms or response and remission rates in treating schizophrenia or bipolar disorder.
  • No class effects for either benefits or adverse effects of antipsychotics can be assumed based on the evidence to date.
  • The evidence base about comparative effectiveness and safety is inadequate for informed decisionmaking because of sparse data, imprecise effect estimates, and concerns about study usefulness (high risk of bias, wide variety of outcome measures).