First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Other Report Findings: Outcome Modifiers
For schizophrenia, the effect of race on treatment resistance provided the most data. No notable differences were observed for the subgroups when compared with overall findings. The race most often examined was Asian.
Findings analyzed by bipolar disorder subtype (bipolar 1 or bipolar 2) were consistent with overall findings.
Haloperidol was more effective than ziprasidone for core illness symptoms (Young Mania Rating Scale and total score) for patients with bipolar 1 disorder.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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