First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Results of Comparative Effectiveness Studies of Antipsychotics as Treatment for Bipolar Disorder
No statistically significant difference in assessment of mania, depression, or global impressions of bipolar disorder is noted in comparisons of haloperidol and aripiprazole. The strength of evidence for this finding is low.
No statistically significant difference in total score for mania assessment is found in comparisons of haloperidol with olanzapine or risperidone. The strength of evidence for this finding is low.
In bipolar disorder, haloperidol produces lower relapse rates than aripiprazole and provides better response rates than ziprasidone. The strength of evidence for this finding was not rated.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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