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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

Slide: 26 of 35

Summary of Studies of Bipolar Disorder Included in the Comparative Effectiveness Review

Studies of efficacy, effectiveness, benefits, and adverse effects of antipsychotics for the approved indication of bipolar disorder were evaluated in the systematic comparative effectiveness review. Many different scales were used to assess outcomes, so the quantitative pooling of data in the comparative effectiveness review was limited.

No trials compared the effectiveness of the first-generation antipsychotics fluphenazine, perphenazine, trifluoperazine, and thioridazine with second-generation antipsychotics.

Haloperidol was compared with aripiprazole in two studies, with olanzapine in two studies, with quetiapine in one study, with risperidone in five studies, and with ziprasidone in one study.