First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Summary of Studies of Bipolar Disorder Included in the Comparative Effectiveness Review
Studies of efficacy, effectiveness, benefits, and adverse effects of antipsychotics for the approved indication of bipolar disorder were evaluated in the systematic comparative effectiveness review. Many different scales were used to assess outcomes, so the quantitative pooling of data in the comparative effectiveness review was limited.
No trials compared the effectiveness of the first-generation antipsychotics fluphenazine, perphenazine, trifluoperazine, and thioridazine with second-generation antipsychotics.
Haloperidol was compared with aripiprazole in two studies, with olanzapine in two studies, with quetiapine in one study, with risperidone in five studies, and with ziprasidone in one study.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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