First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Summary of Results: FGAs Versus SGAs for Treating Schizophrenia
Few differences were found in comparisons of the first-generation antipsychotic haloperidol with the second-generation antipsychotics. Clinical significance, defined as at least a 20-percent difference between interventions on an individual scale, was rarely found.
When compared with haloperidol, olanzapine may provide clinically significant, greater improvement in negative symptoms (Positive and Negative Syndrome Scale [PANSS], Scale for the Assessment of Positive Symptoms [SANS]), total scores (PANSS), and measures of general psychopathology (Hamilton Depression Scale [HAM-D], Montgomery-Asberg Depression Rating Score [MADRS]). The strength of evidence for this finding was moderate.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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