First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Comparative Effectiveness of FGAs and SGAs for Treating Schizophrenia: Response and Remission Rates
Few statistically significant differences in other outcomes (e.g., response and remission rates, utilization of the health care system) were found.
When compared with haloperidol, risperidone yields better relapse rates and olanzapine provides better response and relapse rates in patients with schizophrenia. The strength of evidence for this finding was not rated.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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