First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Comparative Effectiveness of FGAs and SGAs for Treating Schizophrenia: Other Comparisons (1 of 2)
The evidence is insufficient to permit conclusions from comparisons of fluphenazine with the second-generation antipsychotics (SGAs) and about comparison of chlorpromazine with olanzapine, quetiapine, and ziprasidone.
The first-generation antipsychotic perphenazine was compared to several SGAs in the well-known National Institute of Mental Health-sponsored CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) trial, which found no statistically significant differences in effectiveness between perphenazine and the SGAs. However, the evidence remains insufficient to permit conclusions about comparative effectiveness.
- Lieberman JA, Stroup TS, McEvoy JP, et al; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005 Sep 22;353(12):1209-23. PMID: 16172203.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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