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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

Slide: 22 of 35

Comparative Effectiveness of FGAs and SGAs for Treating Schizophrenia: Other Comparisons (1 of 2)

The evidence is insufficient to permit conclusions from comparisons of fluphenazine with the second-generation antipsychotics (SGAs) and about comparison of chlorpromazine with olanzapine, quetiapine, and ziprasidone.

The first-generation antipsychotic perphenazine was compared to several SGAs in the well-known National Institute of Mental Health-sponsored CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) trial, which found no statistically significant differences in effectiveness between perphenazine and the SGAs. However, the evidence remains insufficient to permit conclusions about comparative effectiveness.