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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

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Comparative Effectiveness of Haloperidol and SGAs for Treating Schizophrenia: Positive Symptoms

Haloperidol and second-generation antipsychotic s(SGAs) were compared for effectiveness in treating positive symptoms of schizophrenia. The assessment instruments commonly used were the Positive and Negative Syndrome Scale (PANSS) and the Scale for Assessment of Positive Symptoms (SAPS).

No statistically significant difference in effect was noted using the PANSS in studies that compared haloperidol with olanzapine (14 randomized controlled trials [RCTs]), quetiapine (4 RCTs), risperidone (20 RCTs), or clozapine (2 RCTs). No statistically significant difference in effect was noted using the SAPS in studies that compared haloperidol with olanzapine and risperidone (2 RCTs). The strength of evidence is low for each of these findings.