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First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness

Slide: 16 of 35

Modes of Results Reporting and Statistical Analysis in the Comparative Effectiveness Review

95-Percent Confidence Interval (95% CI): The range of statistically valid results that will include the true population mean in 95 of 100 repeated experiments

Mean Difference (MD): The difference between treatment and comparison group means

  • For MD the result is statistically significant (p < 0.05) when the 95% CI does not include 0.0, which is the point of no difference between groups.

Relative Risk (RR): The ratio of the rate (absolute risk, probability) of an event in the treatment group to the rate of the event in the comparison group

  • For RR, the result is statistically significant at p < 0.05 when the 95% CI does not include 1.0, which is the point of equal risk for both groups.

Clinically Significant Difference: At least a 20-percent difference between treatments on an individual assessment scale