First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Modes of Results Reporting and Statistical Analysis in the Comparative Effectiveness Review
95-Percent Confidence Interval (95% CI): The range of statistically valid results that will include the true population mean in 95 of 100 repeated experiments
Mean Difference (MD): The difference between treatment and comparison group means
- For MD the result is statistically significant (p < 0.05) when the 95% CI does not include 0.0, which is the point of no difference between groups.
Relative Risk (RR): The ratio of the rate (absolute risk, probability) of an event in the treatment group to the rate of the event in the comparison group
- For RR, the result is statistically significant at p < 0.05 when the 95% CI does not include 1.0, which is the point of equal risk for both groups.
Clinically Significant Difference: At least a 20-percent difference between treatments on an individual assessment scale
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
- Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions. Version 5.1.0. London: The Cochrane Collaboration; March 2011. Available at www.cochrane-handbook.org.
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