First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Adverse Effects of Interest in the Comparative Effectiveness Review
The adverse effect profiles of the antipsychotics are not expected to vary according to indication. Key adverse effects identified prior to analysis in the systematic review were mortality, weight gain, endocrine disorders and diabetes, cardiovascular events, extrapyramidal symptoms, and sedation.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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