First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
Clinically Significant Outcomes of Interest in the Comparative Effectiveness Review (1 of 3)
A variety of validated assessment instruments are used to measure outcomes of treating schizophrenia and bipolar disorder with antipsychotics.
Scales are used both in practice and in clinical studies. Remission rates and changes in symptom severity are reported. Response rate is defined as the proportion of participants achieving a degree of improvement (specified a priori) on a rating scale. The primary instruments used in the included studies and analyzed in the comparative effectiveness review are presented in tables in the following slides.
- Abou-Setta AM, Mousavi SS, Spooner C, et al. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. Comparative Effectiveness Review No. 63 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC054-EF. Available at www.effectivehealthcare.ahrq.gov/antipsychotics-adult.cfm.
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