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Drug Therapy for Rheumatoid Arthritis in Adults

Slide: 16 of 45

Analytic Methods Used in the Systematic Review

To compare study results systematically, the authors identified these minimally clinically important differences:

  • American College of Rheumatology 20-percent improvement criteria (ACR20): Finding a statistically significant difference in the proportion of patients achieving ACR20 between treatment and control groups
  • A disease activity score (DAS) of <1.6
  • A DAS28 of <2.6
  • Functional ability: Difference between treatment and control groups in Health Assessment Questionnaire score is ≥0.22
  • Health-related quality of life: The difference in the SF-36 (Medical Outcomes Study Short Form) is 2.6–4.4 for physical component score
  • A change in joint damage of 5.0 according to the Sharp/van de Heijde method