Drug Therapy for Rheumatoid Arthritis in Adults
Summary of Study Characteristics Evaluated in the Comparative Effectiveness Review: PICOTS
Development of clinical studies of effectiveness of medical interventions is guided by the PICOTS (population, interventions, comparators, outcomes, timing, and setting) framework. These items are critical elements that will help to answer important clinical questions. In the comparative effectiveness review, the clinical study literature was reviewed and summarized by using the PICOTS framework. The evidence concerning the outcomes identified here was examined in:
Interventions: oral and biologic DMARDs and corticosteroids
Comparators: Other DMARDs, other active interventions, placebo, or no active intervention
- Symptom response and remission, general health and quality of life
- Key adverse effects: mortality, infusion and injection reactions, infections, malignancy, and rare but serious events
Timing: Any time point, ranging from 12 weeks to months/years
Setting: All settings
Keywords: rheumatoid arthritis | RA | DMARDs | disease-modifying | antirheumatic | anti-rheumatic | rheumatic | biologic | oral | PICOTs
- Donahue KE, Jonas D, Hansen RA, et al. Drug Therapy for Rheumatoid Arthritis in Adults: An Update. Comparative Effectiveness Review No. 55 (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I). Rockville, MD: Agency for Healthcare Research and Quality; April 2012. AHRQ Publication No. 12-EHC025-EF. Available at www.effectivehealthcare.ahrq.gov/dmardsra.cfm.
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